Phd Position: Dopaminergic Control of Locomotor - Sherbrooke, Canada - Université de Sherbrooke

Université de Sherbrooke

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Sherbrooke, Canada

2 weeks ago

Posted by:

Sophia Lee

beBee Recruiter

Description

PhD position:

Dopaminergic control of locomotor circuits:

Réf

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ABG-110461

Sujet de Thèse 25/01/2023
Financement public/privé
Université de Sherbrooke
Lieu de travail
Sherbrooke
Canada
Intitulé du sujet
PhD position: Dopaminergic control of locomotor circuits
Champs scientifiques
Psychologie, neurosciences

Mots clés

Dopamine, neuroscience, locomotion
Description du sujet:

The locomotor role of dopaminergic cells is classically attributed to their ascending projections to the basal ganglia that project to brainstem locomotor circuits.

However, descending projections to brainstem locomotor circuits were uncovered (Ryczko et al. PNAS 2013, PNAS 2016, J Neurosci 2017, J Neurosci In lamprey, this descending pathway increases locomotor activity. In mammals, the role of such innervation remains to be determined.

The student will address this issue in mice using in vivo optogenetics, fiber photometry, movement analysis, patch-clamp electrophysiology, calcium imaging, and viral tracing.

The new knowledge will provide a better understanding of the relation between dopaminergic and locomotor neurons and help identify new clinical strategies to improve locomotor function in Parkinson's disease.

Prise de fonction:

01/09/2023
Nature du financement:
Financement public/privé

Précisions sur le financement:

Canadian Institute for Health Research
Présentation établissement et labo d'accueil:
Université de Sherbrooke

HOST LABORATORY:
Pr.

Ryczko has expertise in the neural control of locomotion and published research in excellent journals (PNAS, Science, Journal of Neuroscience ).

The lab receives grant support by the CIHR, NSERC, FRQS, CFI and ERC.

We are equipped for optogenetics, viral injections, patch-clamp recordings, confocal and two photon calcium imaging, high-resolution movement analysis based on deep learning, and microscopy (confocal, light-sheet, two-photon, STED).

Sherbrooke is located at the heart of the Canadian nature and offers one of the best quality of life in Canada.

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Intitulé du doctorat: