Scientist Ii Analytical Development - Toronto, Canada - BlueRock Therapeutics

BlueRock Therapeutics

Verified Company

Toronto, Canada

2 weeks ago

Posted by:

Sophia Lee

beBee Recruiter

Description

Who is BlueRock?

BlueRock Therapeutics, a wholly-owned and independently operated subsidiary of Bayer AG, is a leading engineered cell therapy company using its unique
_cell+gene_ platform to direct cellular differentiation and genetically engineer cells to create a new generation of cellular medicines that address large patient populations suffering from neurological, cardiovascular, and immunology diseases.

The convergence of cell biology and genetic engineering is creating fundamental new ways to impact disease.

Founded in 2016 to capitalize on these technological breakthroughs, we are advancing our novel
_cell+gene_ platform to develop, manufacture, and deliver an entirely new generation of authentic and engineered cell therapies across three therapeutic areas:
neurology, cardiology, and immunology.

What Are We Doing?

Our foundational science harnesses the ability to create and then direct the differentiation of universal pluripotent stem cells into authentic, functional cells that can be used as allogeneic cellular therapies to treat a broad array of diseases.

We can also further engineer these cells, enabling them to produce enzymes, antibodies, and other proteins for additional therapeutic benefit.

We are passionate about delivering on the promise of cellular and gene therapy, shaping the future of cellular medicine, and delivering new therapies to millions of patients with treatment options.

We are seeking individuals who are collaborative, thrive in a fun and dynamic culture, and are steadfast in the commitment to advance cutting-edge cellular therapies to impact patients' lives.

Responsibilities:

Design, develop and optimize analytical methods to support iPSC cell banking and cell therapy manufacturing processes with a focus on genomic characterization methods.
Ensure that assays meet requirements for the intended use of the assays, which includes characterization, lot release, stability and comparability testing of development and manufacturing batches and establish phaseappropriate specifications.
Champion evaluating and implementing new technologies and analytical methods to characterize PSC starting materials and differentiated drug substances.
Analyze experimental data to draw conclusions that support decision making and next steps within and across projects.
Perform other cellular and/or molecular assays as required.
Prepare and present project plans and regular project progress updates and recommendations.
Document experimental data in electronic laboratory notebooks in a timely and accurate manner in accordance with the company quality management system.
Prepare, review, and approve experimental protocols, reports, standard operating procedures and other scientific and quality documents.
Requires handson laboratory work in addition to training and supervision of junior staff members in supporting analytical activities within the AD team.
Identify and evaluate new technologies and incorporate them into product quality assessments as appropriate.
Present scientific data to colleagues in group meetings, prepare and present internal and external presentations as required.
Contribute to building a culture that embraces scientific excellence, integrity, urgency, courage, and community.

Minimum Requirements:

Advanced (PhD or MSc) degree in biological sciences, or similar with 2+ (PhD) or 11+ (MSc) years or 12+ (BSc) of relevant experience, preferably in an industry environment.
Significant handson experience in developing and optimizing genomic characterization methods, such as droplet digital PCR (ddPCR), whole genome sequencing (WGS), optical genome mapping (OGM), fluorescence _in situ_ hybridization (FISH) and/or SNP arrays.
Experience in clinical cytogenetics is an asset.
Handson experience in mammalian cell culture is required.
Strong preference for experience in the Biotechnology setting, particularly cell therapy, pluripotent stem cells, gene editing.
Experience with automated liquid handlers is an asset.
Practical knowledge of statistical analysis of data is required.
Knowledge and understanding of statistical programming languages (R, python, etc.) and Design of Experiments (DoEs) is preferred.
Proven ability to structure, plan, and execute experiments and independently execute complex tasks in a fastpaced environment.
Excellent organizational and problemsolving skills, with demonstrated ability to work crossfunctionally.
Proficiency in technical scientific writing.
Excellent interpersonal, verbal and written communication skills.
Experience with GxP guidelines/documentation and general GxP experience in analytical development is an asset but not required.

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BlueRock Therapeutics Company Culture Highlights
Winner of Boston Business Journal's Best Places to Work (Mid-size Company) 2023

Winner of Comparably's Award for Best Company for Diversity 2022

Winner of Comparably's Award for B