Research Associate in Tuberculosis Drug Discovery - Vancouver, Canada - University of British Columbia

University of British Columbia
University of British Columbia
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Vancouver, Canada

1 day ago

Sophia Lee

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Sophia Lee

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Description
Academic

Job Category

Faculty Non Bargaining

Job Title

Research Associate In Tuberculosis Drug Discovery

Department

Av-Gay Laboratory Division of Infectious Diseases | Department of Medicine | Faculty of Medicine (Yossef Av-Gay)

Posting End Date

Note:
Applications will be accepted until 11:59 PM on the day prior to the Posting End Date above.

Job End Date

Jun 2, 2026

The expected pay for this position is $68,932/annum (prorated:27,


A research associate position is available in Professor Yossef Av-Gay's laboratory at UBC Department of Medicine, Division of Infectious Diseases.


Research Description:

  • Mycobacterium tuberculosis_ (Mtb), the etiological agent of tuberculosis (TB), is one of the most devastating infectious agents in the world. One third of the world's population is exposed to Mtb, which kills nearly two million people annually. With the increasing prevalence of drugresistant TB, there is a pressing need for better and new drugs against Mtb.


Macrophages are key components of the human innate immune system with a defined role of seeking and destroying invading microorganisms.

Mtb, however, can neutralize the macrophage's killing machinery. While isolated inside the phagosomes, Mtb avoids key components of the host immune system.

As such, TB disease progression relies on the intimate interaction between the host macrophage and the invading microbe whereby recognition, control and elimination of Mtb are mediated by host signal transduction proteins.

The work is funded by a Canadian Institute of Health Research (CIHR) grant and various industrial partners. For a description of the laboratory activities please refer to


Qualifications:


  • 5 years prior experience in microbiological techniques, cellbased assays and medicinal chemistry or drug discovery
  • A Ph.
D. in Microbiology or Biochemistry (or related disciplines)

  • Related work experience and peerreviewed publications
  • Strong oral and proven written communication skills
  • Excellent organization skills and be able to work effectively within a team environment
Responsibilities will include, but will not be limited to:

  • Performing literature and systematic reviews related to TB drug development
  • Staying updated on literature advancing the emerging science of causes and related strategies, to treat infectious diseases.
  • Performing High Throughput and High Content Screening Experiments.
  • Performing Biochemical and genetic validation studies
  • Coordinating external experiments
  • Developing reports and manuscripts for publication
  • Preparing and delivering presentations for research meetings
  • Providing other support as required to Av-Gay's lab team
Supervision
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