Associate Scientist, Impurities Assays - Vancouver, Canada - AbCellera Biologics
Description
AbCellera is an energetic, and rapidly growing tech company with an amazing team that searches, decodes, and analyzes natural immune systems to find antibodies that its partners can develop into drugs to prevent and treat disease.
Working at the interface of computation, engineering, and biology, AbCellera is rebuilding the front-end process of how drugs are discovered with a discovery platform that integrates modern technologies from engineering, microfluidics, single-cell analysis, high-throughput genomics, machine learning, and hyper-scale data science.
With over 500 AbCellerites and growing, we're expanding our capabilities to include CMC development and GMP manufacturing of antibodies to bring therapies from idea to patients, faster.
We are seeking a highly motivated Associate Scientist to join the Impurities Assay team within CMC Analytical Development at AbCellera.
In this capacity, the Associate Scientist will be responsible for assisting in establishing platform impurities assays supporting both Quality Control and Process Development.
How you might spend your days
- Designing and executing the development and qualification of assays supporting the identification and quantitation of processrelated impurities (Ex. host cell proteins, host cell DNA, residual protein A, insulin, etc)
- Collaborating with the research organization to align on technology and methodology between labs
- Performing processrelated impurity testing with mínimal supervision
- Working with the QC organization for technology transfer of assays and associated reagents
- Supporting internal recipients of impurities assays through training/troubleshooting
- Independently compile, analyze and interpret data
- Managing and executing analytical requests from process development; returning accurate and robust impurities results in a timely manner
- Authoring technical reports related to assay qualification and characterization activities
- Presenting experimental findings within the department, across the CMC organization, and to the broader Scientific organization
Required skills and experience
- A BSc degree in Biochemistry, Microbiology, Chemistry, Molecular Biology, or other life science with 5+ years of experience or an MSc degree with 24 years experience
- Technical proficiency in platebased assay (Ex. ELISA) development, qualification, and troubleshooting
- Experience with molecular biology techniques including, but not limited to, 1D/2DGel Electrophoresis, Western blotting, qPCR, etc
- Strong data and time organization/management skills
- Proficiency working with data acquisition platforms related to immunoassays (Ex. Softmax Pro)
- Familiarity with electronic lab notebooks (Ex. Benchling), experimental data capture, and the associated 21 CFR part 11 compliance requirements
- Demonstrated ability to learn, understand, and master new experimental techniques
- Experience with CMC analytical development of monoclonal antibodies or related biotherapeutic proteins
- Knowledge of regulatory filings such as INDs, BLAs, IMPDs, etc would be advantageous
- Proven yourself to be a problemsolver and team player with strong written and verbal communication skills
- Familiarity with regulatory requirements as it pertains to CMC activities for monoclonal antibodies (FDA, EMA, ICH, etc)
What we offer
A generous compensation package including an equity stake in AbCellera's success. Our headquarters are nestled in the heart of Vancouver, Canada - we'll support you and your family in every way we can to relocate if you haven't had the joy of living in this beautiful area
About AbCellera
At AbCellera, we're solving tough problems and creating innovative solutions from the ground up - custom immunizations, microfluidics, high-throughput imaging, genomics, computation, machine learning and laboratory automation.
You'll join a diverse and multi-disciplinary team of biologists, biochemists, engineers, bioinformaticians, computer scientists and physicists - all working together to bring better therapies to patients.
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