Bioinformatician - Toronto, Canada - Sinai Health

Sinai Health

Verified Company

Toronto, Canada

3 weeks ago

Posted by:

Sophia Lee

beBee Recruiter

Description

Sinai Health is a leading academic health science centre with a provincial, national and international reputation for discovering and delivering life-changing care.

Since 2015, we have provided excellent and compassionate care in hospital, community and home.

Comprised of Mount Sinai Hospital, Bridgepoint Active Healthcare, the Lunenfeld-Tanenbaum Research Institute and our system partner Circle of Care, we translate scientific breakthroughs, push boundaries for health solutions, and educates future clinical and scientific leaders.

At Sinai Health, we care, create possibilities and offer hope. We are looking for an experienced Bioinformatician in our Diagnostic Medical Genetics department.

Reporting to the Senior Manager of Diagnostic Medical Genetics (DMG), the Bioinformatician is an integral member of a multi-disciplinary clinical and academic team specializing in both prenatal and predictive molecular diagnostics.

This role will be shared between the cytogenetics and molecular diagnostics labs within the Division of Diagnostic Medical Genetics and is familiar with genomic microarray technologies and cancer diagnostics, and is proficient in data analysis, data mining, interpretation and the preparation of statistical reports.

Duties and Responsibilities:

_Sequencing Analysis Pipeline_

Development and maintenance of bioinformatics pipelines for analyzing microarray and nextgeneration sequencing (germline/somatic variant and fusion calling) data
Manage the storage of nextgeneration sequencing data
Utilize external database to assist in the annotation and assessment of sequencing data
Evaluate and implement novel bioinformatics tools to improve standard of care for genetic testing

_ Software Development_

Develop software solutions to aid diagnostic staff and optimize laboratory processes
Manage software upgrades and ensure compliance to regulatory standards
Assist in troubleshooting of vendor hardware and software issues related to sequencing
Assist in development, maintenance, and troubleshooting of Laboratory Information Management System (LIMS)
Assist in the development, maintenance and troubleshooting of the integration of LIMS and the Laboratory Information System (LIS)
Assist in the creation and maintenance of standard of procedure documents for analysis software

_ Quality Assurance_

Evaluate key performance metrics by querying and analyzing data from LIMS and LIS to identify bottlenecks and/or opportunities for improvement in current practice
Provide operational and strategic reports and participate in service planning to track performance metrics on a regular basis
Assist in the implementation of quality improvement initiatives through data analysis and software development

_ Additional duties _

Assist in the training of laboratory staff in the use of LIMS
Attend regular staff meetings, team huddles and discipline meetings where appropriate
Collaborate with clinical staff, clinical directors and laboratory staff on multidisciplinary projects
Consult with laboratory staff to identify project and user requirements
Respects client confidence and protects operations by keeping information confidential
Retain technical knowledge by attending educational workshops; reviewing publications; establishing personal networks; participating in technical societies on a continual basis
Contributions to the writing of publications

Job Requirements

Bachelors/Masters Degree in Bioinformatics/Computer Science/Computational Biology or related field
Experience in academic/industrial environment for data analysis of nextgeneration sequencing data for germline variant calling, somatic variant calling, and/or fusion calling required
Minimum 1 year experience in software development in multiple programming languages, such as Python/Java, and derivatives for biological data analysis
Experience with Linux/UNIX based systems and developing shell scripts/commandline interface for data processing
Basic understanding of databases (Oracle/MySQL), fundamental database design principles and SQL
Strong interpersonal communication skills, both written and verbal
Proven organizational skills and ability to manage multiple priorities in a busy work environment
Experience with Microsoft Excel, Microsoft Access, and VBA
Experience with LIS used in a clinical laboratory settings
Familiarity with various biomedical databases
Basic understanding of statistics