Gaser Abdelrasoul

Motivated and well-organized professional with +6 years of experience in R&D, bioanalytical and analytical chemistry, assay developments, and the design, execution, transfer, and validation of analytical experiments and stability studies. Team player thrives in cross-functional team environments with solid problem-solving and communication skills, forestalls potential issues, and initiates a fast response. Well-versed in developing cost-effective solutions to complex problems using innovative methodologies, data analysis, data validation, and documentation.

• Bioanalytical techniques for biomolecules and biomolecule-nanoparticle hybrids characterization: Tecan automated liquid handler, ELISA, SPR, gel column chromatography, electrophoresis, PCR, qPCR, flow cytometry, and cell labeling for diagnosis
• Analytical techniques for chemical molecules: UV-Vis, FTIR, DLS, NTA, wet chemistry, ICP-OES, MS, HPLC, and LC-MS for organic, inorganic, and organic-semiconducting hybrid materials
• Microscopic analytical techniques: optical microscope, TEM, SEM, SEM/EDX, and confocal laser scanning microscope
• Design, execute, and validate analytical testing, stability, and compatibility studies for pharmaceutical and biological hybrid molecules following DOE principles SOPs and safety measures EHS, GMP, and GLP
• Data collection and analysis using software such as Excel, GraphPad Prism, and OriginLab to conduct drift control and background correction for complex samples.
• Liaise between R&D and the quality control team to transfer the quality validation, production, and scaling up protocols and performance qualification documents
• Manage multiple research projects and support the technical development and troubleshooting of instruments to develop reagent kits for biotechnology and pharmaceutical applications.
• Prepare plans, scope, progress reports, and presentations; participate in meetings; communicate with other departments
• Provide guidance and training to junior scientists and technicians covering safety and health, environmental, and technical aspects.

RELEVANT EXPERIENCE

Senior Scientist, Vital Biosciences, Mississauga ON, Canada – Sept 2022 – present

• Design and execute characterization and stability investigations for antibody-nanoparticle hybrids and active ingredients to build recognition elements for a diagnostic platform, saving 50,000 per month on outsourcing reagents
• Employ the TECAN Freedom Evo automated liquid handler to run ELISA immunoassays, gel electrophoresis, gel column chromatography, DLS, fluorescent, UV-Vis, and TEM to validate antibody complexes’ stability and compatibility, improving shelf-life over 3 months, minimizing non-specific binding, and boosting the sensitivity by 300%
• Provide training and guidance in the design and execution of ICP-OES, TEM, PL, DLS, and FTIR characterization, including troubleshooting, method implementation, and safety support.
• Create and review experimental reports, SOPs, and safety documents to support the research activities in the lab.

Research Scientist, Coloursmith Labs Inc., Halifax NS, Canada - Aug 2021 – Sept 2022                                                                                                           

• Developed QA/QC testing for the developed nanocapsules and incoming active ingredients following GLP, enhancing the encapsulation efficiency
• Conducted MS, GPC, TEM, and FTIR on organic nanocapsules, DLS, and an optical microscope to confirm the encapsulation of the active small molecules 
• Documented the experimental results, wrote and updated SOPs for the new instruments, and prepared and delivered presentations summarizing the project results.

Research Scientist, Tricca Inc., Hidaca Inc., UofA Edmonton, AB, Canada – Dec 2015 – Jul 2021 

• Developed antibody-nanoparticle hybrids, designed and executed purification and characterization using column chromatography, TEM, DLS, ICP-OES, SEM, and gel electrophoresis for cell labeling and diagnostic applications, resulting in a total budget of $800,000 and two patents
• Performed qPCR, PCR, and ELISA to validate the developed antibody-nanoparticle and DNA-nanoparticle recognition elements and smart gene nanocarriers, estimating the sensitivity and stability
• Conducted HPLC, GC-MS, LC-MS, crystallization, XRD, NMR, MS, UV-Vis, PL, and FTIR analysis for active pharmaceutical ingredients to validate their structure and estimate the impurity level.
• Collaborated with a cross-functional team to build wet chemistry processes to purify and conduct stability investigations for pharmaceutical materials and antibody complexes following GMP and GLP
• Conducted data aggregation, analysis, and interpretation using different statistical methods, and wrote and reviewed technical reports.

Research Scientist, PDF Istituto Italiano Di Tecnologia, Genova, Italy – May 2012 – May 2015                                                                                                   

• Performed confocal laser microscope imaging, SEM/EDX, and flow cytometry to verify the cell labeling agents, and ELISA for the immunoassay recognition elements
• Conducted qualitative and quantitative analysis using UV-Vis, FTIR, MS, ICP-OES, confocal laser scanning microscope, HPLC, LC-MS, GC-MS, TEM, SEM, fluorescent microscope, XPS, and XRD to validate the structure and properties of the developed nanoparticle hybrids and the reagents.

Ph.D.: Nanobiotechnology, Neuroscience, Drug Discovery, and Material science

Università Degli Studi DI Genova – Department of Chemistry and Industrial Chemistry, Genova, Italy, 2012

Diploma: Nanomedicine Diagnostics and Therapeutics 

The University of Oxford – Department of Chemistry, Department of continuous education, Oxford, UK, 2010