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    Postdoctorant(e) - Montreal, Canada - Centre de recherche de l\'Hôpital Maisonneuve-Rosemont

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    L'équipe de Dr Affar s'intéresse à la signalisation cellulaire via l'ubiquitination et sa dérégulation dans le cancer. L'ubiquitination est un processus réversible dû à la présence des déubiquitinases (enzymes qui enlèvent spécifiquement l'ubiquitine des protéines cibles). L'objectif est de caractériser les fonctions biologiques et les mécanismes d'action des déubiquitinases impliquées dans la transcription et la réparation de l'ADN, deux processus dont la dérégulation joue un rôle fondamental dans le développement du cancer. Présentement, l'équipe travaille particulièrement sur le gène suppresseur de tumeurs BAP1, un gène fréquemment muté dans certains types de cancers. Le laboratoire utilise des approches de biochimie, de biologie moléculaire et de culture cellulaire, à la fine pointe de la technologie, afin de caractériser les fonctions des déubiquitinases.

    L'équipe de recherche du Dr. El Bachir Affar cherche à recruter des stagiaires postdoctorauxs très motivés. Les candidats doivent avoir un PhD en biologie moléculaire ou biochimie ou une discipline connexe, des compétences organisationnelles, et un vif intérêt pour la signalisation cellulaire et l'oncologie moléculaire.

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