Lead Scientist I - Toronto, Canada - Centre for Commercialization of Regenerative Medicine

Centre for Commercialization of Regenerative Medicine

Verified Company

Toronto, Canada

3 weeks ago

Posted by:

Sophia Lee

beBee Recruiter

Description

About CCRM:

Position Summary:

You will be involved in ensuring scalability and robustness of allogeneic iPSC processes for future Good Manufacturing Practices (GMP) manufacturing, and development of analytical methods for quality control (QC) release and characterization of cell and gene therapy products.

Responsibilities:

Provide scientific leadership, project management, and operational oversight of assigned projects related to iPSC reprogramming, genome engineering, and differentiation protocols for academic and industry clients.
Responsible for data generation, collection, interpretation and communication of results.
Prepare and follow standard operating procedures and other process documentation.
Attend and present scientific data at internal and external meetings.
Develop and improve your skills and knowledge to successfully support assigned projects.
Work effectively with other team members in a multidisciplinary environment.
Perform cell culture and analytical testing, as required, for key experimental objectives.
Engage external customers and partners to understand and overcome workflow challenges.
Drive effective communication across the organization.
Work within project teams to identify and prioritize future project opportunities.
Demonstrate integrity and a positive attitude in daily performance, and establish credibility to motivate others to do the same.
Provide guidance and project leadership, as assigned, to junior staff.

Requirements:

PhD in bioengineering, chemical engineering, bioprocess, biotechnology, cell biology, or a related field with 13+ years of relevant industry work experience; or, MSc with 5+ years of relevant industry work experience.
Experience in a biotechnology industry with a particular focus in process development, process scaleup, process analytics, analytical product testing, technology transfer, or manufacturing.
Competent in mammalian cell culture (specifically human iPSCs), including passaging, isolation, expansion, cryopreservation and characterization.
Experience with characterization assays for cells and proteins (e.g. flow cytometry, PCR, qPCR, cloning).
Handson experience or strong understanding of iPSC reprogramming and differentiation methods.
Handson experience with mechanisms of DNA repair used for gene editing (i.e. CRISPR/Cas9).
Solid scientific approach with deep experience in experimental planning, design (DoE), statistical analyses, interpretation, documentation and communication.
Excellent communication and intrapersonal skills.
Independent, detailoriented, selfstarter with excellent analytical skills and the ability to multitask and succeed in a team environment.
Must be flexible to support research activities outside of normal business hours, as needed.
Primarily a labbased role, with people and project leadership responsibilities, as directed.

Desired Characteristics:

Experience with process development, process optimization, analytical development and optimization, workflow simplification, and culture intensification for cells.
Experience in immune and/or gene therapy manufacturing production platforms in either wavemixed (e.g. Xuri Bioreactors) or stirred tank reactors (e.g. DasBOX and Bioflo/BioBLU bioreactors).
Experience in upstream (isolation, activation, transduction, expansion) and downstream (harvest, volume reduction, buffer exchange, fill and cryopreservation) processing workflows with immune cell populations and associated challenges.
Experience in advanced genetic analysis (e.g. NGS) and in using software for genetic design/analysis.
Experience working with customers.
People and team management skills are an important asset.

CCRM is a developing organization and represents a fluid working environment. Flexibility and adaptability are essential, and duties will be influenced by the needs of the organization.

Applicants must be legally eligible to work in Canada.

CCRM is committed to accessibility, diversity, and equal opportunity.

Requests for accommodation can be made at any stage of the recruitment process, providing the applicant has met the bona fide requirements for the open position.

Applicants should make their requirements known once contacted to schedule an interview, or when the job offer has been made.