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    Pilot Plant Senior Manager - Vancouver, Canada - AbCellera

    AbCellera
    AbCellera Vancouver, Canada

    6 days ago

    Default job background
    Description

    AbCellera is breaking the barriers of conventional drug development to propel antibody-based medicines from target to clinic. We are a team of scientists, engineers, creatives, and business professionals who believe that advancing science enhances lives. We have developed technologies to unlock high-value drug targets, including antibody-drug conjugates and T-cell engagers for cancer, and complex transmembrane proteins for indications such as metabolic and endocrine conditions, pain, and autoimmunity.

    We are seeking a Pilot Plant Senior Manager to provide technical and strategic leadership as we design, implement and operationalize a 200L scale pilot manufacturing facility to generate material for CMC development, including providing representative material of high quality for regulatory submission enabling GLP toxicology studies.

    How you might spend your days

  • Providing strategic, technical and tactical leadership within the manufacturing, science & technology team through oversight of a 200L scale pilot manufacturing facility
  • Providing technical and scientific expertise and leadership for process optimization, scale-up, technology transfer and troubleshooting
  • Providing scientific leadership and project management for multiple early stage development projects
  • Championing high safety standards within the pilot plant
  • Detailed planning, coordination, implementation, tracking and communication to ensure material delivery whilst maintaining the production schedule for all technical Pilot Plant operations
  • Taking ownership and responsibility for the successful completion (as measured by product yield, quality & consistency, and the achievement of project timelines) of manufacturing campaigns
  • Providing a science-based approach for the evaluation and testing of new technologies / equipment to reduce cost of goods and streamline process development and manufacturing
  • Implementing and overseeing a robust equipment management and maintenance system, including oversight of and interaction with the site based support functions including the Facility Engineering and Metrology teams
  • Overseeing supply chain needs of the Pilot Plant, including working with materials management on ensuring critical supplies are available and in stock as well as, being the point person for new equipment or supplies required for new technology transfers into the Pilot Plant

    • We'd love to hear from you if you

  • Have 8-12 years of industrial experience in process development, manufacturing, and/or MSAT, ideally working with antibodies, and a minimum of 4 years in a leadership role
  • Hold a bachelors or masters education in biotechnology, chemical/biochemical engineering, or another relevant life-science discipline
  • Have experience in scale-up, technology transfer, batch documentation and data management
  • Have demonstrated experience in leadership and managing direct reports including, developing and training teams to operate pilot scale manufacturing equipment
  • Have strong pilot-scale process and product data analysis skills, and practical experience for the establishment of processes and procedures for driving new investigational medicinal products forward
  • You have familiarity with regulatory requirements as it pertains to CMC activities for biologics (FDA, EMA, ICH, etc). Experience authoring regulatory filings such as INDs, BLAs, IMPDs etc. would be advantageous
  • Have a passion for developing people and teams, and a proven track record establishing process development and/or manufacturing capabilities
  • Thrive in a fast-paced environment with a high level of urgency and evolving priorities, and apply pragmatic, risk-based decision making to process development and manufacturing

    • What we offer

    AbCellera's hiring range for this role is $139,000 - $173,800 CAD annually, commensurate with your education and job-related knowledge, skills, and experience. In addition to base salary, we offer equity, an annual bonus dependent on team and company performance, and a 6% (non-match) RRSP contribution.

    We have a number of ways to support AbCellerites in maximizing their work-life synergy. You will have a $1,500 annual Active Lifestyle Allowance, annual vacation, the opportunity for flexible work arrangements, professional development opportunities, and comprehensive health benefits. Scientific and technical mentorship is a priority. And you'll find abundant teams and social groups to build community and connections across AbCellera.

    About AbCellera

    AbCellera is a global company that discovers and develops antibody-based medicines that help people live longer, happier, and more productive lives. We are focused on bringing innovative medicines to patients, both by advancing our internal pipeline of programs and partnering with companies that have novel science or innovative technology.

    And it all starts with our team. We've built a place where people feel they are part of something bigger than themselves. A place that exists to push the limits of science and technology, and aims to bring better therapies to patients.

    We look for people with drive and energy. Idealists. People we love and people we trust. This may be unconventional, but it is the key to our success.

    #LI-EM1

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